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Pancreatic most cancers, which impacts about 60,000 Individuals yearly, is without doubt one of the deadliest types of most cancers. After prognosis, fewer than 10 % of sufferers survive for 5 years.
Whereas some chemotherapies are initially efficient, pancreatic tumors typically turn out to be immune to them. The illness has additionally confirmed troublesome to deal with with newer approaches similar to immunotherapy.
Dr Steve Bigelsen
As a doctor who doesn’t follow different or complementary therapies, he’s conscious of the hurdles and arguments towards recommending non-FDA authorised therapies and has a number of issues himself. He believes that if these issues are adequately addressed, we are able to fill a void that’s sorely missing between sufferers searching for one thing experimental to enhance their odds of survival (a lot of whom flip to inappropriate, futile different therapies) and the legit scientific neighborhood who has actual hope to supply.
Pancreatic Most cancers and CA19-9 Tumor Marker Ranges
The graph beneath shows the check outcomes of a Stage 4 Pancreatic Most cancers affected person’s tumor marker ranges over time.
http://whsc.emory.edu/analysis/morningside/2019-conference-bios.html
The decrease the CA19-9, typically, the decrease the most cancers exercise. Inside days of including a repurposed drug cocktail to straightforward remedy, this affected person’s CA19-9 stage dropped like a stone, quicker than any of his Oncologists had seen with this sort of most cancers. The repurposed medicine he added have been Hydroxychloroquine and Paricalcitol – a type of injectable Vitamin D.
A standard CA19-9 stage in somebody with out most cancers is beneath 35. This affected person with terminal Pancreatic most cancers noticed his ranges drop from 11,500 to beneath 35 in about three months. Nonetheless, he was not a median affected person; he was himself a doctor.
Dr. Stephen Bigelsen has taught at Rutgers College Medical College as a professor in Allergy and Immunology. He’s a scientist and goes by the e book. He researched his most cancers and spoke to others who did extra particular analysis, and he didn’t settle for the consensus commonplace of care. As an alternative, he innovated, and he stays alive, some 5 years later, totally recovered from Pancreatic Most cancers. Like Ivermectin, Hydroxychloroquine and Paricalcitol are repurposed medicine. They’re deemed protected and efficient by the FDA for an additional illness, but utilized in most cancers after exhibiting scientific promise.
Like Ivermectin, the FDA and regulators hate the thought of repurposed medicine as a result of they’re getting used with out their permission or approval. Regardless, it’s authorized for physicians to prescribe them in the event that they consider, based mostly upon their data and expertise, it might assist and even save a life. Within the case of Dr. Bigelsen, it was his personal life that was saved.
QUESTIONS:
#1. Suppose nobody survives Stage 4 Pancreatic Most cancers utilizing commonplace remedy – the usual remedy of chemo/radiation/surgical procedure obtained by Alex Trebek, Patrick Swayze, and Michael Landon. Why do not we INFORM ALL most cancers sufferers that repurposed medicine are an choice? Should you be a doctor like Dr. Stephen Bigelsen to get the repurposed cocktail? Most of us would by no means know even to ask.
Should a affected person come across a e book that explains this?
Only a few folks come across repurposed medicine for most cancers. Consequently, 99.999% by no means get the kind of remedy that Dr. Bigelsen did. And he tells his story that getting right into a medical trial just isn’t all that useful when you get just one drug, or solely get the placebo, or when you wait till the late phases when most cancers has returned in a resistant state.
Getting right into a medical trial in any case else fails in most cancers care is simply too little, too late. It might assist the research, nevertheless it often does little for the affected person. Dr. Bigelsen received all of the medicine began by writing a prescription for himself, one thing most of us can not do.
The repurposed drug cocktails MUST BE STARTED EARLY.
It’s the identical with COVID-19. The sooner one begins the Ivermectin, the higher. In India, whole households would start the Ivermectin the second one member of the family received sick. This technique proved remarkably efficient, and it didn’t produce deaths, strokes, or blood clots.
What’s the level of all this? 1.9 million Individuals contract most cancers every year, and 600,000 die from the illness. These numbers, in my view, might be diminished by 1/3 by the widespread adoption of repurposed drug cocktails. Sadly, the usual of care for many cancers stays Chemo/Radiation/Surgical procedure. I write quite a bit concerning the SAM cocktail, a mix of Statin/Aspirin/Metformin. Dr. Bigelsen writes about this as properly.
Does hydroxychloroquine kill most cancers?
A 2017 evaluation — which reviewed greater than 190 research investigating how chloroquine (CQ) and hydroxychloroquine (HCQ) have an effect on most cancers cells — describes how the malaria medicine could improve tumor sensitivity to present most cancers therapies.
Primarily based on their findings, first research creator Ciska Verbaanderd, from the College of Leuven in Belgium, and her colleagues say that the medicine “deserve additional medical investigations in a number of most cancers sorts.”
The
Whereas america has seen a fall in most cancers demise charges lately, the illness stays a big burden on public well being. Final yr, there have been greater than 1.6 millionTrusted Supply new most cancers circumstances identified within the U.S. and greater than 595,000 most cancers deaths.
Provided that most cancers is more and more turning into immune to present therapies, there’s a determined must uncover new methods to combat the illness.
Verbaanderd and colleagues consider that the medicine CQ and HCQ may assist on this combat.
CQ and HCQ are medicines used to stop and deal with malaria. They might even be used within the remedy of lupus and rheumatoid arthritis. A wealth of
For his or her evaluation, Verbaanderd and colleagues analyzed the outcomes of greater than 190 animal and human research that assessed the consequences of CQ and HCQ on several types of most cancers.
Based on the researchers, the intention of their evaluation was “to tell additional analysis and trials on repurposing CQ and HCQ as anti-cancer brokers.”
The workforce uncovered proof to counsel that CQ and HCQ might be efficient for the remedy of a variety of cancers, together with glioblastoma — which is a lethal mind most cancers — lung most cancers, and pancreatic most cancers.
“CQ and HCQ have been studied in a number of preclinical most cancers fashions,” write the authors, “and have demonstrated exercise on a number of cancer-supporting pathways and together with a broad vary of different therapies.”
“[…] The vast majority of these research have reported an improved therapeutic efficacy as in contrast with monotherapy with present anti-cancer medicine,” they add.
The evaluation additionally signifies that each medicine are “protected and tolerable” as an anti-cancer remedy, although present proof means that HCQ would possibly pose fewer uncomfortable side effects.
Based on the workforce, their evaluation highlights a variety of mechanisms by which CQ and HCQ may assist to deal with most cancers.
Firstly, there’s proof to counsel that the medicine can inhibit autophagy, which is the method whereby cells devour their very own broken or pointless parts.
“Autophagic properties similar to nutrient recycling can assist most cancers cell survival,” the authors notice. “Furthermore, key regulators of cell development might be degraded and the DNA harm response might be suppressed via elevated autophagy.”
“Subsequently, inhibition of autophagy might be an fascinating anti-cancer technique when most cancers cells begin relying on autophagy for survival.”
The evaluation additionally revealed that CQ and HCQ can block the CXCL12/CXCR4 signaling pathway, which earlier analysis has related to most cancers development.
Moreover, there’s proof that CQ can stabilize a protein known as p53, which is a identified tumor suppressor, and it might additionally assist to normalize blood vessel dysfunction in tumors.
“The advantages of vessel normalization embrace a lower in tumor hypoxia, diminished most cancers cell intravasation and metastasis, and a rise in chemotherapeutic drug supply and response,” the authors clarify.
Total, Verbaanderd and colleagues consider that their research has highlighted the potential advantages of CQ and HCQ as a most cancers remedy, in addition to the mechanisms behind their anti-cancer properties.
The workforce notes that there are 30 medical trials at the moment investigating the consequences of CQ and HCQ towards numerous most cancers sorts.
Primarily based on their evaluation, the researchers conclude that these trials ought to deal with the efficacy of those medicines, in addition to the very best doses and strategies of administration.
References:
Case report: stage 4 pancreatic most cancers to remission utilizing paricalcitol and hydroxychloroquine along with conventional chemotherapy by Stephen Bigelsen: I’m a doctor specializing in Allergy and Bronchial asthma, who in July 2016, had tumors within the head and the tail of the pancreas with scattered peritoneal metastases and a CA19-9 of 11,575 U/mL. Working with physicians from Weill-Cornell and Johns Hopkins, I started remedy with gemcitabine and capecitabine, plus IV Paricalcitol (25 mcg 3x’s/week) and hydroxychloroquine (600 mg BID). These are each protected and cheap remedy choices which have proven success in pre-clinical fashions, section 2 human trials, and are available. I’ve now loved a full response with my newest CA19-9 of simply 15 U/mL and no proof of energetic illness on my most up-to-date CT scan.
Hydroxychloroquine in Beforehand Handled Sufferers With Metastatic Pancreatic Most cancers Hydroxychloroquine is authorised for the remedy of non-cancerous diseases similar to rheumatoid arthritis and systemic lupus erythematous. Researchers within the laboratory have examined tumors from sufferers with pancreatic most cancers and have found that they’ve sure pathways contained in the cells that promote development and survival of the tumor. Hydroxychloroquine could inactivate these pathways and ends in the demise of pancreatic most cancers cells.
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