I’ve been getting a whole lot of emails a few new Xyngular product referred to as GLP-X. As the corporate web site says, ‘GLP-X is a premium complement formulation crafted from naturally sourced substances clinically studied to extend GLP-1 manufacturing.* (observe asterisk that results in disclaimer that none of those claims have been evaluated by the FDA) It isn’t nearly managing weight—it’s about elevating your outcomes.’

As a registered dietitian, I’m all the time inquisitive about taking a better take a look at these types of firms and their dietary supplements, as a result of all too typically, I discover that they sidestep the reality, and the analysis, within the curiosity of constructing gross sales.

This GLP-X overview examines the claims that Xyngular and its salespeople are making about this product, what GLP-1 is, and if we will actually ‘hack’ it with food regimen and dietary supplements to imitate the motion of GLP-1 agonists like Ozempic.

What’s GLP-1?

GLP-1, or glucagon-like peptide-1, is a peptide hormone that’s produced within the gut. Its job is to stimulate insulin (which brings glucose into cells, and is why GLP-1 medicine have been initially accepted as drugs for diabetes), and inhibit glucagon (glucagon will increase blood sugar and fatty acids within the blood when meals isn’t current). 

GLP-1 additionally slows down gastrointestinal motility, which makes us really feel fuller for longer. Therefore, weight reduction (and certain, negative effects like vomiting for some people who find themselves on GLP-1 agonist meds).

How do GLP-1 agonists like Ozempic work?

I wrote about Ozempic and different GLP-1 agonists for weight reduction right here

All of us have GLP-1 receptors in our physique. GLP-1 agonists are analog variations of our personal GLP-1 (related, however not precisely the identical), they usually work by binding to and activating our physique’s GLP-1 receptors. 

When this occurs, we see the identical results as those I described above: elevated insulin and decreased glucagon, and slowed motility with ensuing fullness. 

GLP-1 agonists have confirmed to be extraordinarily secure and efficient for weight reduction, however predictably, there are folks and corporations desirous to make their very own buck by convincing others that ‘Huge Pharma’ is the enemy and that ‘pure’ GLP-1 dietary supplements are so a lot better than precise medicine.

Try this submit about Xyngular GLP-X:

The marketing of Huge Pharma conspiracy theories whereas spouting the Enchantment to Nature fallacy (pure is best! OMG SYNTHETIC MEDICATION!) is a basic gross sales tactic that’s sadly changing into extra frequent, particularly amongst multi-level advertising salespeople. It’s improper, deceptive, and simply plain opportunistic, which is the principle purpose why, as a dietitian, I selected to put in writing this submit. 

Everybody ought to concentrate on this form of factor. Oh, and in addition, this complement is NOT ‘backed by 3 medical trials.’ Not even shut. See how MLM salespeople can principally say something to promote product?

Horrible. Additionally: a 30 day provide of GLP-X prices $75 USD. Not precisely what I’d name ‘reasonably priced.’

Can we enhance our GLP-1 naturally utilizing meals and dietary supplements?

Let’s begin with the meals a part of the equation.

There are particular meals which might be recognized to extend ranges of GLP-1 in our our bodies. Excessive-fibre grains, eggs, nuts, and avocado are amongst them, in line with this 2016 overview.

Particularly, mono and polyunsaturated fat, proteins, and fermentable fibre (fermentation within the intestine to short-chain fatty acids will increase GLP-1 ranges) from grains, legumes, and a few fruits like apples and inexperienced bananas. Analysis on this space is fairly hit and miss although, and as typical I’m reluctant to take animal research and extrapolate them to people. 

It’s secure to say that even when we eat meals that enhance GLP-1 ranges in our our bodies, this doesn’t even strategy the effectiveness of GLP-1 agonists for weight reduction. 

Let’s take into consideration this for a second – we’ve had entry to those meals eternally. Would we swiftly uncover that they’ve these magical weight reduction powers past what we already know?

I extremely doubt it.

My suggestions listed here are the identical as all the time: numerous fibre, ample protein, wholesome fat. Can’t lose. 

So far as dietary supplements, as with meals, there have been none which have proven the extent of effectiveness of GLP-1 agonist drugs. 

If a complement does have related efficacy to precise GLP-1 agonist meds for weight reduction, it possible won’t be offered by a multi-level advertising firm. It will likely be regulated by the FDA and used as a reputable remedy.

What’s Xyngular?

Xyngular is an MLM firm that sells vitamin merchandise. 

I did an up to date Xyngular overview on my web site in 2020, and I doubt a lot has modified with the corporate since then.

Right here’s a few of Xyngular’s product lineup. Typical fats burners, ‘craving controllers, and intestine well being boosters.

Most if not all vitamin MLM firms make use of the identical methods to make gross sales (and that is on no account an exhaustive record):

Huge claims which might be not possible to again up

Lack of oversight of their salespeoples’ social media posts

Poor or no analysis on their merchandise

Fixed upsells

Making the most of ladies who need to make an earnings

I wrote about my points with MLMs and their coaches right here, however let’s simply say that Xyngular is unremarkable amongst its MLM friends. 

What’s Xyngular GLP-X?

Xyngular GLP-X is a complement that’s being marketed as an alternative choice to GLP-1 agonist drugs for weight reduction and ‘GLP-1 help.’ What’s that, anyhow? I wasn’t conscious that our GLP-1 wanted to be supported.

Made up time period with imprecise well being declare = crimson flag.

It comes with all the typical bells and whistles of a newly launched MLM product – full court docket press gross sales throughout social media by the Xyngular salespeople, cute little graphics that inform us principally nothing scientific, and naturally, magical and fantastical guarantees that this little bottle incorporates the reply to all of our issues…no prescription required!

Xyngular GLP-X substances

Herbs and chromium and proprietary blends, oh my! Right here’s what GLP-X has in it:

Carb administration mix

This proprietary mix incorporates Eriomin and berberine. That is the precise mix in Xyngular GLP-X that the corporate states will increase GLP-1. 

Eriomin is a patented citrus bioflavonoid nutraceutical complement. A each day dose (2 capsules) of GLP-X incorporates 250mg of Eriomin.

The place have I heard about Eriomin earlier than? Oh, proper! The Glucose Goddess’s subsequent complement, Anti-Spike, incorporates it as effectively. I wrote all about Anti-Spike right here, and simply to repeat what I stated about Eriomin in that case, there are two research about this citrus extract and blood glucose. Each are comparatively unremarkable by way of blood sugar discount. 

One of many research, accomplished in 2019, noticed a 15% rise in GLP-1 with dosages of 200-800 mg of Eriomin over 12 weeks. Nevertheless, researchers discovered it had no impact on physique weight, BMI, lean mass, fats mass, fats share, and hip waist ratio. 

The 12-week 2022 research that includes Eriomin discovered a 17% rise in GLP-1 with 200 mg a day of the ingredient. Nevertheless, physique weight and BMI remained unchanged. 

You’ve most likely heard me bang on and on in regards to the significance of ‘medical relevance,’ and that is the right time to indicate you what I imply. 

Within the above research, we see that GLP-1 ranges have been certainly increased after supplementation with Eriomin. This sounds nice, till you’re wanting to make use of this ingredient to advertise weight reduction. As a result of though there was a major change within the research topics’ GLP-1, nothing actually occurred to their weight whereas these ranges have been elevated. 

It principally didn’t change a factor round weight. 

Repeat after me: it could be ‘vital,’ however that doesn’t imply it’s clinically related to us!

So far as Berberine, we do know that it has constructive results for rising GLP-1 and for lowering blood glucose in folks with diabetes. Nevertheless, berberine doesn’t decrease blood glucose by rising GLP-1 within the physique; it promotes insulin secretion and improves glucose regulation, amongst different mechanisms.

Once more, medical relevance of this ingredient for GLP-1-related weight reduction? In all probability none. 

GLP-X additionally incorporates a proprietary ‘water steadiness mix,’ in any other case often called a diuretic. Peeing out fluids doesn’t equal ‘weight reduction.’ Or, ought to I say, ‘fats loss.’ 

Then there’s the proprietary ‘urge for food help mix,’ which incorporates the standard suspects: inexperienced espresso bean, 5-ATP, and phytosterols, none of which have ever been confirmed to facilitate vital weight reduction in people.

Even so, a ton of multi-level marketed merchandise proceed to place these substances of their weight reduction merchandise. Sadly, science doesn’t care how laborious you want for one thing to work so your product may be the ‘subsequent neatest thing.’

A phrase about proprietary blends: I like to recommend not buying merchandise that comprise proprietary blends. These are principally smokescreens that firms can disguise behind so that they don’t must reveal the precise quantities of substances which might be of their merchandise. It might be slightly, it might be lots. It might be the efficient dose (assuming any of the substances are efficient in any respect), it might be much less. For GLP-X, for instance, we don’t know how a lot Berberine or Eriomin is in every capsule. It’s a roulette wheel that I don’t suggest spinning together with your pockets or your well being.

GLP-X has two extra substances which might be equally underwhelming for weight reduction and results on GLP-1: chromium and magnesium.

Nothing about these two minerals will increase weight reduction or GLP-1. That’s all.

What? However I believed GLP-X is ‘backed by 3 medical trials’?

The truth that Xyngular and its salespeople can say that the substances on this product are ‘clinically studied to extend GLP-1’ makes most individuals suppose that 1. GLP-X itself has constructive research behind it (it doesn’t) and a couple of. the substances ship clinically related and significant outcomes for GLP-1 resulting in weight reduction. 

Nope to all of that, nevertheless it’s a advertising tactic I see actually on daily basis with dietary supplements. It’s deceptive and it’s disappointing. 

Does Xyngular GLP-X work?

Whereas among the substances in Xyngular GLP-X have been proven to enhance blood glucose administration in some folks, there isn’t a analysis to indicate that the GLP-X complement itself truly does what Xyngular claims it does.

There are many GLP-X testimonials, however these are simply faked, and guess what? MLM coaches like to submit them, however conveniently neglect to submit the not-so-glowing evaluations, too.

Why are we so determined to look a sure approach, that we belief our well being to those firms and their salespeople, most of whom have zero related well being coaching and who don’t care about our well being, solely their gross sales? Please don’t.

So far as ‘pure’ GLP-1 dietary supplements, these are extra delusion than truth. Simply because one thing will increase our GLP-1 ranges doesn’t imply that this results in the burden loss results we’d see with GLP-1 agonist drugs. The truth is, the analysis is fairly clear that in most (if not all) instances, it doesn’t.

Save your $75.