Recognized since historical instances as a “treatment for all the things however dying,” an more and more huge physique of scientific analysis reveals that black seed is certainly considered one of nature’s most potent and versatile therapeutic brokers.

Just a few years in the past, we wrote an article about Nigella sativa (aka black seed) titled, “The Treatment for All the things however Dying.” It described the analysis on the numerous methods during which black seed is a probably lifesaving medicinal meals, and is considered one of our hottest articles, with over 700 thousand social media shares and near 2 million views.

Opening with, “This humble however immensely highly effective seed kills MRSA, heals the chemical weapon-poisoned physique, stimulates regeneration of the dying beta cells throughout the diabetic’s pancreas, and but too few even comprehend it exists,” the article summarized the peer-reviewed and revealed analysis on 10 of the seed’s outstanding well being advantages:

• Sort 2 diabetes: Two grams of black seed a day resulted in diminished fasting glucose, decreased insulin resistance, elevated beta-cell operate, and diminished glycosylated hemoglobin (HbA1c) in human topics. [R]
• Helicobacter pylori an infection: Black seeds possess clinically helpful anti-H. pylori exercise, akin to triple eradication remedy. [R]
• Epilepsy: Black seeds had been historically recognized to have anticonvulsive properties. A 2007 research with epileptic kids, whose situation was refractory to traditional drug remedy, discovered {that a} water extract considerably diminished seizure exercise. 
• Hypertension: The each day use of 100 and 200 milligrams of black seed extract, twice each day, for 2 months, was discovered to have a blood pressure-lowering impact in sufferers with delicate hypertension. 
• Bronchial asthma: Thymoquinone, one of many essential energetic constituents inside Nigella sativa, is superior to the drug fluticasone in an animal mannequin of bronchial asthma. [6] One other research, this time in human topics, discovered that boiled water extracts of black seed have a comparatively potent anti-asthmatic impact on asthmatic airways. 
• Acute tonsillopharyngitis: Characterised by tonsil or pharyngeal irritation (i.e. sore throat), principally viral in origin, black seed capsules (together with Phyllanthus niruri) have been discovered to considerably alleviate throat ache, and cut back the necessity for painkillers in human topics. 
• Chemical-weapons damage: A randomized, placebo-controlled human research of chemical weapons-injured sufferers discovered that boiled water extracts of black seed diminished respiratory signs, chest wheezing, and pulmonary operate take a look at values, in addition to diminished the necessity for drug remedy. 
• Colon most cancers: Cell research have discovered that black seed extract compares favorably to the chemo agent 5-fluorouracil within the suppression of colon most cancers progress, however with a far larger security profile. [10] Animal analysis has discovered that black seed oil has vital inhibitory results towards colon most cancers in rats, with out observable unintended effects. [R]
• MRSA: Black seed has antibacterial exercise towards medical isolates of methicillin-resistant Staphylococcus aureus (MRSA). 
• Opiate dependancy/withdrawal: A research on 35 opiate addicts discovered black seed as an efficient remedy within the long-term remedy of opioid dependence. 

Because the article’s publication, the biomedical analysis on black seed has continued to flourish, with dozens of latest articles revealed and cited within the Nationwide Library of Drugs’s biomedical database, out there to peruse.

16 Further Potential Well being Advantages to Add to the Rising Record

1. Prevents radiation injury: Nigella sativa oil (NSO) and its energetic element, thymoquinone, shield mind tissue from radiation-induced nitrosative stress. [1]
2. Protects towards injury from coronary heart assault: A thymoquinone extract from Nigella sativa has a protecting impact towards injury related to experimental coronary heart assault. [2]
3. Prevents morphine dependence/toxicity: An alcohol extract of Nigella sativa reduces morphine-associated conditioned place choice, a sign of morphine intoxication, dependence, and tolerance. [3]
4. Prevents kidney injury related to diabetes: A thymoquinone extract from Nigella sativa has protecting results on experimental diabetic nephropathy. [4]
5. Prevents postsurgical adhesions: Overlaying peritoneal surfaces with Nigella sativa oil after peritoneal trauma is efficient in lowering peritoneal adhesion formation in an experimental mannequin. [5]
6. Prevents Alzheimer’s-associated neurotoxicity: A thymoquinone extract from Nigella sativa has protecting results on experimental diabetics, and prevents neurotoxicity and A-beta-1-40-induced apoptosis within the cell mannequin. [6]
7. Suppresses breast most cancers progress: A thymoquinone extract from Nigella sativa inhibits tumor progress and induces programmed cell dying (apoptosis) in a breast most cancers xenograft mouse mannequin. [7], [8]
8. Displays anti-psoriasis properties: The alcohol extract of Nigella sativa seeds exhibit anti-psoriatic exercise, according to its medicinal use in conventional medication. [9]
9. Prevents mind pathology related to Parkinson’s illness: A thymoquinone extract from Nigella sativa protects cultured neurons towards alpha-SN-induced synaptic toxicity, a pathology noticed within the brains of sufferers with Parkinson’s illness and dementia with Lewy our bodies. [10]
10. Kills extremely aggressive glioblastoma mind most cancers cells: A thymoquinone extract from Nigella sativa reveals glioblastoma cell killing exercise. [11]
11. Kills leukemia cells: A thymoquinone extract from Nigella sativa induces mitochondria-mediated apoptosis in acute lymphoblastic leukemia in vitro. [12]
12. Suppresses liver most cancers progress: A thymoquinone extract from Nigella sativa prevents chemically induced most cancers in a rat mannequin. [13]
13. Prevents diabetic pathologies: A water and alcohol extract of Nigella sativa at low doses has a blood sugar-lowering impact and ameliorative impact on the regeneration of pancreatic islets, indicating its worth as a therapeutic agent within the administration of diabetes mellitus. [14]
14. Suppresses cervical most cancers cell progress: A thymoquinone extract from Nigella sativa reveals anti-proliferative, apoptotic, and anti-invasive properties in a cervical most cancers cell line. [15]
15. Prevents lead-induced mind injury: A thymoquinone extract from Nigella sativa ameliorates lead-induced mind injury in Sprague Dawley rats. [16]
16. Kills oral most cancers cells: A thymoquinone extract from Nigella sativa induces programmed cell dying (apoptosis) in oral most cancers cells. [17]

Black seed’s advantages are nonetheless largely underreported and underutilized. Why is such a robust seed not but on the radar of most medical and diet communities?

Apparently, regardless of this blind spot, and as if to verify black seed’s immense potential as a therapeutic agent, Nestlé, the Switzerland-based world meals large, filed a patent on the usage of Nigella sativa to “stop meals allergic reactions” in 2010 (Nestlé’s worldwide patent publication WO2010133574). This apparent try to applicable conventional data and use claimed the plant seed or extract needs to be Nestlé’s mental property when used as a meals ingredient or drug. In accordance with a Third World Community Briefing Paper (pdf) from July 2012:

“The Swiss large’s claims seem invalid, as conventional makes use of of Nigella sativa clearly anticipate Nestlé’s patent software, and creating nation scholarship has already validated these conventional makes use of and additional described, in up to date scientific phrases, the very medicinal properties of black seed that Nestlé seeks to assert as its personal ‘invention.’

“Nestlé claims any use of an opioid receptor-stimulating compound to deal with or stop allergic reactions, particularly thymoquinone and, extra particularly, administration of thymoquinone within the type of Nigella sativa plant materials (seeds). The kind of meals allergy of best focus is upset abdomen and diarrhea.”

The excellent news is that no such patent has but to win approval, and for now, this meals remains to be freely out there. For added analysis updates, merely go to PubMed.gov and join an automated e-mail replace for the key phrase “Nigella sativa,” and also you’ll be one of many first to be taught in regards to the new analysis being completed on this superb seed because it comes instantly via the biomedical analysis pipeline.

References

[1] Adem Ahlatci, Abdurahman Kuzhan, Seyithan Taysi, Omer Can Demirtas, Hilal Eryigit Alkis, Mehmet Tarakcioglu, Ali Demirci, Derya Caglayan, Edibe Saricicek, Kadir Cinar. Radiation-modifying talents of Nigella sativa and Thymoquinone on radiation-induced nitrosative stress within the mind tissue. Phytomedicine. 2013 Nov 21. pii: S0944-7113(13)00432-7. doi: 10.1016/j.phymed.2013.10.023. [Epub ahead of print]

[2] Mohammad Akram Randhawa, Mastour Safar Alghamdi, Subir Kumar Maulik. The impact of thymoquinone, an energetic element of Nigella sativa, on isoproterenol induced myocardial damage. Pak J Pharm Sci. 2013 Nov;26(6):1215-9.

[3] Milad Anvari, Atefeh Seddigh, Mohammad Naser Shafei, Hassan Rakhshandeh, Amir Hossein Talebi, Mohammad Reza Tahani, S Mohsen Saeedjalali, Mahmoud Hosseini. Nigella sativa extract impacts conditioned place choice induced by morphine in rats. 2012 Oct;32(2):82-8. doi: 10.4103/0257-7941.118537.

[4] Ola M Omran. Results of Thymoquinone on STZ-induced Diabetic Nephropathy: An Immunohistochemical Examine. Ultrastruct Pathol. 2013 Oct 17.

[5] Ahmet Sahbaz, Firat Ersan, Serdar Aydin. Impact of Nigella sativa oil on postoperative peritoneal adhesion formation. J Obstet Gynaecol Res. 2013 Oct 7. doi: 10.1111/jog.12172.

[6] Norsharina Ismail, Maznah Ismail, Musalmah Mazlan, Latiffah Abdul Latiff, Mustapha Umar Imam, Shahid Iqbal, Nur Hanisah Azmi, Siti Aisyah Abd Ghafar, Kim Wei Chan. Thymoquinone Preventsβ-Amyloid Neurotoxicity in Main Cultured Cerebellar Granule Neurons. 2013 Nov;33(8):1159-69. doi: 10.1007/s10571-013-9982-z. Epub 2013 Oct 8.

[7] Chern Chiuh Woo, Annie Hsu, Alan Prem Kumar, Gautam Sethi, Kwong Huat Benny Tan. Thymoquinone Inhibits Tumor Development and Induces Apoptosis in a Breast Most cancers Xenograft Mouse Mannequin: The Position of p38 MAPK and ROS. 2013 Oct 2;8(10):e75356. doi: 10.1371/journal.pone.0075356. PMID: 24098377

[8] Shashi Rajput, B N Prashanth Kumar, Kaushik Kumar Dey, Ipsita Pal, Aditya Parekh, Mahitosh Mandal. Molecular concentrating on of Akt by thymoquinone promotes G1 arrest via translation inhibition of cyclin D1 and induces apoptosis in breast most cancers cells. 2013 Nov 13;93(21):783-90. doi: 10.1016/j.lfs.2013.09.009. Epub 2013 Sep 15. PMID: 24044882

[9] Lalitha Priyanka Dwarampudi, Dhanabal Palaniswamy, Muruganantham Nithyanantham, P S Raghu. Antipsoriatic exercise and cytotoxicity of ethanolic extract of Nigella sativa seeds. 2012 Oct;8(32):268-72. doi: 10.4103/0973-1296.103650. PMID:24082629

[10] A H Alhebshi, A Odawara, M Gotoh, I Suzuki. Thymoquinone protects cultured hippocampal and human induced pluripotent stem cells-derived neurons againstα-synuclein-induced synapse injury. Neurosci Lett. 2013 Sep 27. pii: S0304-3940(13)00873-2. doi: 10.1016/j.neulet.2013.09.049. PMID: 24080376

[11] Ira O Racoma, Walter Hans Meisen, Qi-En Wang, Balveen Kaur, Altaf A Wani. Thymoquinone inhibits autophagy and induces cathepsin-mediated, caspase-independent cell dying in glioblastoma cells. 2013 Sep 9;8(9):e72882. doi: 10.1371/journal.pone.0072882. PMID: 24039814

[12] Landa Zeenelabdin Ali Salim, Syam Mohan, Rozana Othman, Siddig Ibrahim Abdelwahab, Behnam Kamalidehghan, Bassem Y Sheikh, Mohamed Yousif Ibrahim. Thymoquinone induces mitochondria-mediated apoptosis in acute lymphoblastic leukaemia in vitro. . 2013 Sep 12;18(9):11219-40. doi: 10.3390/molecules180911219. PMID: 24036512

[13] Subramanian Raghunandhakumar, Arumugam Paramasivam, Selvam Senthilraja, Chandrasekar Naveenkumar, Selvamani Asokkumar, John Binuclara, Sundaram Jagan, Pandi Anandakumar, Thiruvengadam Devaki. Thymoquinone inhibits cell proliferation via regulation of G1/S part cell cycle transition in N-nitrosodiethylamine-induced experimental rat hepatocellular carcinoma. 2013 Oct 23;223(1):60-72. doi: 10.1016/j.toxlet.2013.08.018. Epub 2013 Sep 3. PMID:24012840

[14] Samad Alimohammadi, Rahim Hobbenaghi, Javad Javanbakht, Danial Kheradmand, Reza Mortezaee, Maryam Tavakoli, Farshid Khadivar, Hamid Akbari. Protecting and antidiabetic results of extract from Nigella sativa on blood glucose concentrations towards streptozotocin (STZ)-induced diabetic in rats: an experimental research with histopathological analysis. PMID: 23947821

[15] Cagri Sakalar, Merve Yuruk, Tugba Kaya, Metin Aytekin, Salih Kuk, Halit Canatan. Pronounced transcriptional regulation of apoptotic and TNF-NF-kappa-B signaling genes in the course of the course of thymoquinone mediated apoptosis in HeLa cells. Mol Cell Biochem. 2013 Nov;383(1-2):243-51. doi: 10.1007/s11010-013-1772-x. Epub 2013 Aug 14.PMID: 23943306

[16] Khaled Radad, Khaled Hassanein, Mubarak Al-Shraim, Rudolf Moldzio, Wolf-Dieter Rausch. Thymoquinone ameliorates lead-induced mind injury in Sprague Dawley rats. PMID: 23910425

[17] Ehab Abdelfadil, Ya-Hsin Cheng, Da-Tian Bau, Wei-Jen Ting, Li-Mien Chen, Hsi-Hsien Hsu, Yueh-Min Lin, Ray-Jade Chen, Fu-Jenn Tsai, Chang-Hai Tsai, Chih-Yang Huang. Thymoquinone induces apoptosis in oral most cancers cells via p38β inhibition

Tailored from: https://www.theepochtimes.com/well being/16-more-reasons-black-seed-is-the-remedy-for-everything-but-death_5135126.html

Associated: 10 Greatest Methods to Stop Most cancers (Analysis Overview 2023 Version)