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As of November 2023, there are greater than 3,000 research printed associated to the remedy and prevention of COVID-19.

If you’re nonetheless confused in regards to the suggestions made by completely different skilled teams for the COVID-19 pandemic, you’ve got come to the appropriate place.

The variety of choices for the remedy of COVID-19 has elevated drastically in current months, thus making it sophisticated in terms of selecting the best mixture. Typically, there are 3 broad classes of medical interventions:

1. Prevention or Prophylaxis e.g. vaccine
2. Early out-patient remedy
3. Hospital remedy

The assorted remedies out there for various situations typically contain using complicated applied sciences and specialised terminology, which may be overwhelming and complicated for customers. To attain the very best consequence, a number of remedies and methods are sometimes utilized in mixture. Subsequently, it is necessary to work intently together with your healthcare supplier to grasp the completely different choices out there and decide one of the best plan of action to your particular wants.

The medical neighborhood themselves are battling over ivermectin and hydroxychloroquine on whether or not they need to be used to deal with and forestall COVID-19. On one aspect are specialists telling you that extra analysis is required earlier than the remedy may be totally approved and confirmed. On the opposite, are specialists telling you that the potential advantages outweigh the chance and a ‘wait and do nothing’ place just isn’t acceptable. Confused? 

When confronted with conflicting steering from completely different skilled teams, it may be difficult to navigate by the various opinions. One frequent subject is that some teams might have a pre-determined narrative that they want to assist, resulting in cherry-picking of research that align with their views. This strategy may end up in biased and manipulated selections. To acquire a extra correct understanding, it’s essential to investigate scientific data comprehensively, in an up to date and non-biased method. This requires evaluating a broad vary of proof from a number of sources and thoroughly weighing the strengths and limitations of every examine, to reach at an knowledgeable determination.

On this article, we’d cowl 3 standard remedies i.e. Hydroxychloroquine, Ivermectin and Quercetin.

Hydroxychloroquine

COVID sufferers who have been handled with hydroxychloroquine have been much less more likely to die than those that weren’t, in response to a November 2023 examine.

Simply 0.8 % of sufferers at a facility in France who obtained hydroxychloroquine (HCQ) and an antibiotic died, in contrast with 4.8 % of sufferers who did not obtain the drug mixture, French researchers reported on Nov. 1, 2023.

The November 2023 examine got here a couple of month after researchers in Belgium reported in one other observational examine that HCQ with AZ diminished COVID-19 mortality amongst hospitalized sufferers.

Traditionally, hydroxychloroquine was found throughout efforts to synthesize alternate options to quinine as anti-malarials. Is quinine just like hydroxychloroquine? Hydroxychloroquine and quinine are each anti-malarial medication. Nevertheless, hydroxychloroquine just isn’t the identical as quinine as hydroxychloroquine is an artificial drug whereas quinine is a naturally occurring compound present in cinchona bark. 

Quinine, was first acknowledged as a potent antimalarial agent a whole bunch of years in the past. Since then, the helpful results of quinine and its extra superior artificial types, chloroquine and hydroxychloroquine, have been more and more acknowledged in a myriad of different ailments along with malaria.

Is quercetin identical as quinine? No. Quercetin is a phytonutrient whereas quinine is a naturally occurring compound present in cinchona bark and was used as an antimalarial agent. Nevertheless, each quercetin and quinine are recognized to have zinc ionophore properties i.e. they transport zinc into the cells. 

Hydroxychloroquine, developed within the Fifties from chloroquine, an previous anti-malarial drug, is registered in round 60 international locations underneath commerce names similar to Plaquenil, Quensyl and Plaquinol.

 

Hydroxychloroquine, a much less poisonous spinoff of Chloroquine is a extensively used treatment by individuals with lupus or arthritis. 

Hydroxychloroquine and COVID-19

Hydroxychloroquine (HCQ) just isn’t efficient when used very late with excessive dosages over an extended interval, effectiveness improves with earlier utilization and improved dosing. Early remedy persistently reveals constructive results. Destructive evaluations sometimes ignore remedy time, typically specializing in a subset of late stage research.

Dr. Raoult and his co-authors acknowledged {that a} World Well being Group 2021 trial have discovered no advantages for HCQ in opposition to COVID-19. However they mentioned that the trial, which was funded by the World Well being Group and the UK authorities, suffered from “important methodological issues,” together with excessive dosing throughout the first 24 hours.

As of November 2023, there are greater than 350 printed proof of hydroxychloroquine for COVID-19 (c19hcq.org).

Based mostly on the database on C19Early.com (as of November 2023) under: 

• quercetin performs higher than hydroxychloroquine and ivermectin for prevention however 
• ivermectin and hydroxychloroquine are superior than quercetin when it comes to early remedy

Prevention league desk: Quercetin (93%) vs Ivermectin (85%) vs Hydroxychloroquine (33%)

Early Remedy League Desk: Hydroxychloroquine (65%) vs Ivermectin (62%) vs Quercetin (32%)

A big distinction emerges between initiating remedy early versus late. Late remedy is much less more likely to be efficient when in comparison with early intervention. Nevertheless, initiating remedy early presents its personal set of challenges, as it might take a number of days to endure testing, receive a prescription, and have it crammed. 

Contemplating the multitude of research and the dimensions of affected person populations concerned, hydroxychloroquine continues to be one of many high decisions for decreasing COVID-19 mortality (League desk under). If you’re contemplating stockpiling hydroxychloroquine, it’s advisable to seek the advice of with a medical physician on-line beforehand.

Credit score: C19Early.org

Do you want a prescription for hydroxychloroquine?

Sure, hydroxychloroquine is a prescription drug and also you do want it to be prescribed to you by a physician.

Associated: Discover a Physician who will prescribe Hydroxychloroquine

Ivermectin and COVID-19

Ivermectin is an anti-parasitic treatment extensively utilized in low- and middle-income international locations to deal with parasitic worm infections in adults and youngsters. It’s been used for many years for this function by over 3.7 billion individuals, and is taken into account secure and efficient. It has an rising record of indications as a consequence of its antiviral and anti inflammatory properties, and is included on the WHO’s Mannequin Checklist of Important Medicines.

As of November 2023, there are greater than 90 research on ivermectin and COVID-19. Take a look at the proof tracker on ivermectin and COVID-19 from c19ivermectin.com (continuously up to date).

Is ivermectin a zinc ionophore? Though there are a lot of articles stating it’s however most articles don’t present scientific references to assist the declare. Now we have discovered research that confirmed that ivermectin has a possible ionophore nature: 

• Ivermectin, antiviral properties and COVID-19: a potential new mechanism of motion (Naunyn Schmiedebergs Arch Pharmacol. 2020).
• The multitargeted drug ivermectin: from an anti-parasitic agent to a repositioned most cancers drug (Am J Most cancers Res. 2018)

Ivermectin and FLCCC Protocols

The Entrance Line COVID-19 Crucial Care (FLCCC) Alliance was initially shaped as a working group throughout the early COVID-19 pandemic days in response to a number of early experiences of COVID sufferers with an inexplicably excessive want for extended mechanical air flow and an extreme demise fee.

Based mostly on quickly rising medical trials proof, the FLCCC crew has developed a number of protocols:

• I-PREVENT (COVID Safety), 
• I-CARE (Early at-home remedy), 
• I-RECOVER (Publish-Vaccine remedy)

Considerations and Cautions:

• Ivermectin has numerous doubtlessly critical drug-drug interactions. Please verify for potential drug interplay at Ivermectin Drug Interactions – Medication.com. A very powerful drug interactions happen with cyclosporin, tacrolimus, anti-retroviral medication, and sure anti-fungal medication. 
• Quercetin and ivermectin interactions? In accordance with Medication.com: “No interactions have been discovered between ivermectin and Quercetin. This doesn’t essentially imply no interactions exist. At all times seek the advice of your healthcare supplier.”
• Ivermectin can also be lipophilic and subsequently, bioavailability is maximised on a full abdomen; or greatest to be taken with meal.

Ivermectin for COVID-19: Actual-time meta evaluation

Take a look at the true time meta-analysis on Ivermectin and COVID-19 from Ivmmeta.com (continuously up to date).

Associated: 

• Checklist of Medical doctors that can prescribe Ivermectin

• Checklist of Pharmacies that can fill Ivermectin

Quercetin and COVID-19

Are there dietary supplements just like hydroxychloroquine? Quercetin acts as a zinc ionophore (PubMed 2014), the identical mechanism of motion that hydroxychloroquine has through serving to zinc move the cell wall the place it would halt viral replication.

This zinc ionophore exercise of quercetin facilitates the transport of zinc
throughout the cell membrane. It’s recognized that zinc will decelerate the
replication of coronavirus by inhibition of enzyme RNA polymerase (PubMed 2010). The COVID-19 is an RNA (RiboNucleicAcid) virus and requires the RNA polymerase to duplicate. Do take word that the examine publication was a 2010
publication and is referring to a special coronavirus as in comparison with the
newest coronavirus (COVID-19); although each are from the identical household of
coronaviruses.

A evaluation printed in The Sage Journal (Dec 2020), summarizes the antiviral significance of quercetin and proposes a potential technique for the efficient utilization of pure polyphenols in our each day eating regimen for the prevention of viral an infection.

An animal examine printed within the Nature (Aug 2012), concluded that quercetin has anti-oxidant, anti-inflammatory and anti-fibrotic (anti-scarring) properties. One other examine (JCI Might 2012) on rutin (quercetin molecule certain to a sugar molecule referred to as rutinose), generally present in vegatables and fruits and offered over-the-counter as a dietary complement, has been proven to inhibit the formation of blood clots in an animal mannequin of thrombosis.

As of August 2023, there have been greater than 10 printed research of quercetin in opposition to COVID-19. For the record of research, take a look at c19quercetin.com.

Quercetin, Zinc and Vitamin C

By the way, ascorbic acid (vitamin C) and the bioflavonoid quercetin
(initially labeled vitamin P) have been each found by the identical scientist
— Nobel prize winner Albert Szent-Györgyi. Quercetin and vitamin C additionally act as an antiviral drug, successfully
inactivating viruses. 

There may be proof that vitamin C and quercetin co-administration
exerts a synergistic antiviral motion as a consequence of overlapping antiviral and
immuno-modulatory properties and the capability of ascorbate to recycle
quercetin, rising its efficacy.

Quercetin can also be a part of the FLCCC I-MASK+ protocol and Zelenko protocol for COVID-19.

For up to date prevention protocol (COVID-19 constructive), please take a look at FLCCC I-MASK+ protocol.

Associated: 

• Checklist of Medical doctors that can prescribe early remedy
• Greatest Pulse Oximeter
• Greatest Mouthwashes for COVID-19

Quercetin works greatest when taken with vitamin C and Bromelain, as vitamin C helps activate it and bromelain helps with the absorption. On this examine (PubMed), Bromelain additionally has anti-viral property in opposition to COVID-19 virus and anti-clotting property, and subsequently could also be helpful in opposition to COVID-19.

Warning: Quercetin has one average drug interplay with warfarin. Don’t take quercetin with out medical recommendation in case you are utilizing warfarin.

Ivermectin vs Hydroxychloroquine vs Quercetin

Scientific proof thus far has reported promising outcomes (see above) for
Ivermectin in prevention, early remedy in addition to late remedy for
COVID-19. Whereas each Ivermectin and Hydroxychloroquine may be helpful for
early remedy, Ivermectin has a broader potential profit i.e. prevention,
early remedy in addition to late remedy / hospital remedy. An necessary to notice is that each ivermectin and hydroxychloroquine carry out higher when given early (inside first 3 – 5 days of signs) versus late remedy.

Hydroxychloroquine and Quercetin are each zinc ionophores i.e. they
transport zinc into the cells. 

Nevertheless, quercetin is much less potent than HCQ (hydroxychloroquine) as a zinc
transporter, and it doesn’t attain excessive concentrations in lung cells that
HCQ does. Quercetin might assist cut back danger of viral sickness in case you are
mainly wholesome. However it’s not potent sufficient to switch HCQ for
remedy of COVID after you have signs, and it doesn’t adequately get
into lung tissue.

That mentioned, should you merely can not get hydroxychloroquine or ivermectin,
quercetin is a viable stand-in. Quercetin works greatest when taken with
vitamin C and Bromelain, as vitamin C helps activate it and bromelain
helps with the absorption. Don’t forget to mix it with zinc.

Is quercetin a safer different to hydroxychloroquine? Though ivermectin and hydroxychloroquine are comparatively secure medication, they’re nonetheless artificial chemical compounds that may have unwanted effects. Quercetin and Vitamin D, C, Zinc are vitamins that your physique require for optimum well being. Vitamins are safer alternate options particularly in case your danger is low e.g. age under 50 and no different power sickness. 

Different alternate options similar to Betadine mouthwash and Betadine nasal spray are over-the-counter merchandise that you could possibly get simply out of your nearest pharmacy. Importantly, it’s essential to begin the remedy early. There is a massive distinction when it comes to consequence relying on how early your remedy is. 

Talk about together with your physician on the profit vs danger for every remedy. If you’re on a number of drugs, pay attention to supplement-drug interactions which may improve the probabilities of adversarial results.

Hydroxychloroquine, Ivermectin, Quercetin and FLCCC Protocols

Hydroxychloroquine, ivermectin and quercetin are all a part of the newest FLCCC I-PREVENT and I-CARE early remedy protocols.

For up to date prevention protocol and remedy protocol (COVID-19 constructive), please take a look at FLCCC’s I-PREVENT and I-CARE protocols.

Different Early Remedy Choices

For an up-to-date overview of all printed research on early remedy and prevention of COVID-19, we advocate visiting C19Early. 

Abstract

Though ivermectin and hydroxychloroquine are comparatively
secure medication, they’re nonetheless artificial chemical compounds that may have unwanted effects.
Quercetin is a phytonutrient that can profit your physique for optimum
well being. 

For a listing of confirmed advantages of quercetin (by class), take a look at
advantages of quercetin.

Vitamins are safer alternate options particularly in case your danger is low e.g. age
under 50 and no different power sickness. Talk about together with your physician on the
profit vs danger for every remedy. If you’re on a number of drugs, be
conscious of supplement-drug interactions which may improve the probabilities
of adversarial results.

The necessary key takeaway is ‘early’ remedy. That mentioned it’s best to by no means try to self medicate
with out the steering of a licensed medical supplier. If you’re not a medical
physician, you’re more likely to discover the above data overwhelming. The intention of
this text is to empower you with a greater understanding of the choices
out there and to debate the choices together with your medical physician.

Associated: Greatest Quercetin and Zinc Dietary supplements

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Z-Stack Complement

In an effort to make it simpler for sufferers, Dr Zelenko has developed an oral complement that comprises all 4 key elements: vitamin C, quercetin, vitamin D3 and zinc. It’s known as ‘Z-Stack Complement’. 

Z-Stack Vitamin cocktail supplies key elements wanted with a purpose to assist your physique combat off this lethal invader. The Z-Stack Nutritional vitamins are Kosher licensed, GMP licensed and made within the USA.

The price of the Z-STACK vitamin cocktail is $55 per bottle for a one month provide. 

The place to purchase Z-Stack: Right here is the hyperlink: Z Stack Complement 

Observe: To get 10% OFF, please use this coupon code: ONEDAYMD

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